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KMID : 0368820140530060434
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Journal of the Korean Neuropsychiatr Association
2014 Volume.53 No. 6 p.434 ~ p.437
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A Case of Lithium Toxicity within Normal Creatinine Range during Lithium Maintenance Treatment
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Ohm Hye-Sang
Kim Hyoung-Young
Han Seong-Hoon
Kim Bong-Seog
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Abstract
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Lithium is a widely used drug for treatment of bipolar disorder. Because of its narrow therapeutic range and renal toxicity, most clinical guidelines recommend regular monitoring of serum lithium level and kidney function for patients taking lithium. We report on a case of a 20 year-old man with occurrence of lithium toxicity after more than one year of lithium maintenance therapy with daily lithium intake of 900 mg. His serum creatinine level was within normal range at admission and elevated compared to his baseline, but still within normal range when lithium toxicity occurred. Acute kidney injury associated with dehydration, analgesics, and nephrotoxic effect of lithium might be a risk factor of lithium toxicity. This case showed the importance of thorough monitoring of serum creatinine level change even if its elevated result is within normal range in observing renal function of patients treated with lithium.
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KEYWORD
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Lithium toxicity, Creatinine, Bipolar affective disorder, Non-steroidal anti-inflammatory agents
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